Tractostorm: The what, why, and how of tractography dissection reproducibility. Issue 7 (10th January 2020)
- Record Type:
- Journal Article
- Title:
- Tractostorm: The what, why, and how of tractography dissection reproducibility. Issue 7 (10th January 2020)
- Main Title:
- Tractostorm: The what, why, and how of tractography dissection reproducibility
- Authors:
- Rheault, Francois
De Benedictis, Alessandro
Daducci, Alessandro
Maffei, Chiara
Tax, Chantal M. W.
Romascano, David
Caverzasi, Eduardo
Morency, Felix C.
Corrivetti, Francesco
Pestilli, Franco
Girard, Gabriel
Theaud, Guillaume
Zemmoura, Ilyess
Hau, Janice
Glavin, Kelly
Jordan, Kesshi M.
Pomiecko, Kristofer
Chamberland, Maxime
Barakovic, Muhamed
Goyette, Nil
Poulin, Philippe
Chenot, Quentin
Panesar, Sandip S.
Sarubbo, Silvio
Petit, Laurent
Descoteaux, Maxime - Abstract:
- Abstract: Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called " virtual dissection ." Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC‐ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real‐life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and " virtual dissection " across various laboratories and hospitals. Intra‐rater agreement (Dice score) was approximately 0.77, while inter‐rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of aAbstract: Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called " virtual dissection ." Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC‐ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real‐life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and " virtual dissection " across various laboratories and hospitals. Intra‐rater agreement (Dice score) was approximately 0.77, while inter‐rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of a particular bundle without a sufficient reproducibility score could make the analysis and interpretations more difficult. Coordinated efforts by the diffusion MRI tractography community are needed to quantify and account for reproducibility of WM bundle extraction protocols in this era of open and collaborative science. … (more)
- Is Part Of:
- Human brain mapping. Volume 41:Issue 7(2020)
- Journal:
- Human brain mapping
- Issue:
- Volume 41:Issue 7(2020)
- Issue Display:
- Volume 41, Issue 7 (2020)
- Year:
- 2020
- Volume:
- 41
- Issue:
- 7
- Issue Sort Value:
- 2020-0041-0007-0000
- Page Start:
- 1859
- Page End:
- 1874
- Publication Date:
- 2020-01-10
- Subjects:
- bundle segmentation -- diffusion MRI -- inter‐rater -- intra‐rater -- reproducibility -- tractography -- white matter
Brain mapping -- Periodicals
611.81 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0193 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/hbm.24917 ↗
- Languages:
- English
- ISSNs:
- 1065-9471
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4336.031000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 13165.xml