A core outcome set for future endometriosis research: an international consensus development study. (30th March 2020)

• Record Type: Journal Article
• Authors: Duffy, JMN; Hirsch, M; Vercoe, M; Abbott, J; Barker, C; Collura, B; Drake, R; Evers, JLH; Hickey, M; Horne, AW; Hull, ML; Kolekar, S; Lensen, S; Johnson, NP; Mahajan, V; Mol, BW; Otter, A‐S; Puscasiu, L; Rodriguez, MB; Rombauts, L; Vail, A; Wang, R; Farquhar, CM
• Other Names: Daniels Jane P investigator.; Lim Arianne C investigator.; Edmonds Katie investigator.; MacLean Claire E investigator.; Appleton Amy C investigator.; Skelton Sarah investigator.; Byrne Dominic L investigator.; White Rebecca K investigator.; Sardo Margarida investigator.; Fowles Rebecca C investigator.; Ata Baris investigator.; Richatd Sarah A investigator.; Puig Ybanez Casandra C investigator.; Peterson Matthew C investigator.; Elms Jasmin L investigator.; Parks Ann investigator.; De Bie Rocks Bianca L F investigator.; Roe Jodie C investigator.; Doran Ruby investigator.; Ceccaroni Marcello investigator.; Ferreira Ceu A investigator.; Dias Sofia investigator.; Pinnington Tracey investigator.; Laupa‐Santiago Paula investigator.; Turner Marie C investigator.; Schreurs Anneke M F investigator.; Baggot Eleanor investigator.; Socolov Razvan V investigator.; Yossry Menem investigator.; Hodges Tania M investigator.; Barbossa Marina W P investigator.; Mures Târgu investigator.; Lytwyn Tracy L investigator.; Egan‐Reid Sophia E L investigator.; Devlin Susanna C L investigator.; Crees Kira S investigator.; Baldwin Bethany C investigator.; Scott James R investigator.; Gravolin Amy K investigator.; Chapman Errin F investigator.; Bartley Stephanie N investigator.; Hamilton Alicia J investigator.; Thorpe Kirstie J investigator.; Carmody Denise M investigator.; Eyeson Joanna investigator.; Davis Madeleine D investigator.; Henry Jo investigator.; Armour Mike investigator.; Cummings Presley Y F V investigator.; Cook Lisa A investigator.;
• Is Part Of: BJOG. Volume 127:Number 8(2020)
• Page Start: 967
• Page End: 974
• Publication Date: 2020-03-30
• Subjects: Consensus development study -- core outcome set -- endometriosis -- modified Delphi method -- modified nominal group technique; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.16157
• Languages: English
• ISSNs: 1470-0328

Abstract

Abstract : Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy. This paper includes Author Insights, a video abstract available at https://vimeo.com/rcog/authorinsights16157