Preclinical Alzheimer's disease: A systematic review of the cohorts underlying the concept. Issue 4 (7th February 2017)

• Record Type: Journal Article
• Authors: Epelbaum, Stéphane; Genthon, Rémy; Cavedo, Enrica; Habert, Marie Odile; Lamari, Foudil; Gagliardi, Geoffroy; Lista, Simone; Teichmann, Marc; Bakardjian, Hovagim; Hampel, Harald; Dubois, Bruno
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 4(2017)
• Page Start: 454
• Page End: 467
• Publication Date: 2017-02-07
• Subjects: Preclinical Alzheimer's disease -- Systematic review -- Cohort -- Clinical trial -- Longitudinal -- Cross‐sectional -- Biomarker -- Cognition -- Familial Alzheimer's disease -- Neuropathology; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2016.12.003
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract : Preclinical Alzheimer's disease (AD) is a relatively recent concept describing an entity characterized by the presence of a pathophysiological biomarker signature characteristic for AD in the absence of specific clinical symptoms. There is rising interest in the scientific community to define such an early target population mainly because of failures of all recent clinical trials despite evidence of biological effects on brain amyloidosis for some compounds. A conceptual framework has recently been proposed for this preclinical phase of AD. However, few data exist on this silent stage of AD. We performed a systematic review to investigate how the concept is defined across studies. The review highlights the substantial heterogeneity concerning the three main determinants of preclinical AD: "normal cognition, " "cognitive decline, " and "AD pathophysiological signature." We emphasize the need for a harmonized nomenclature of the preclinical AD concept and standardized population‐based and case‐control studies using unified operationalized criteria.