European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials. Issue 6 (28th March 2018)

• Record Type: Journal Article
• Authors: Vermunt, Lisa; Veal, Colin D.; ter Meulen, Lea; Chrysostomou, Charalambos; van der Flier, Wiesje; Frisoni, Giovanni B.; Guessous, Idris; Kivipelto, Miia; Marizzoni, Moira; Martinez‐Lage, Pablo; Molinuevo, José Luis; Porteous, David; Ritchie, Karen; Scheltens, Philip; Ousset, Pierre‐Jean; Ritchie, Craig W.; Luscan, Gerald; Brookes, Anthony J.; Visser, Pieter Jelle
• Is Part Of: Alzheimer's & dementia. Volume 14:Issue 6(2018)
• Page Start: 837
• Page End: 842
• Publication Date: 2018-03-28
• Subjects: Preclinical AD -- Prodromal AD -- Clinical trial -- Participant recruitment -- Research registry -- EPAD; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2018.02.010
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.