Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study. Issue 2 (11th September 2015)

• Record Type: Journal Article
• Authors: Duits, Flora H.; Martinez‐Lage, Pablo; Paquet, Claire; Engelborghs, Sebastiaan; Lleó, Alberto; Hausner, Lucrezia; Molinuevo, José L.; Stomrud, Erik; Farotti, Lucia; Ramakers, Inez H.G.B.; Tsolaki, Magda; Skarsgård, Constance; Åstrand, Ragnar; Wallin, Anders; Vyhnalek, Martin; Holmber‐Clausen, Marie; Forlenza, Orestes V.; Ghezzi, Laura; Ingelsson, Martin; Hoff, Erik I.; Roks, Gerwin; de Mendonça, Alexandre; Papma, Janne M.; Izagirre, Andrea; Taga, Mariko; Struyfs, Hanne; Alcolea, Daniel A.; Frölich, Lutz; Balasa, Mircea; Minthon, Lennart; Twisk, Jos W.R.; Persson, Staffan; Zetterberg, Henrik; van der Flier, Wiesje M.; Teunissen, Charlotte E.; Scheltens, Philip; Blennow, Kaj;
• Is Part Of: Alzheimer's & dementia. Volume 12:Issue 2(2016)
• Page Start: 154
• Page End: 163
• Publication Date: 2015-09-11
• Subjects: Lumbar puncture -- Cognitive disorders -- Alzheimer's disease -- Memory clinic -- Post‐LP complications -- Post‐LP headache -- Multicenter study on LP feasibility; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2015.08.003
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient‐acceptance of LP, incidence of and risk factors for post‐LP complications in memory clinic populations. Methods: We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post‐LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results: A total of 1065 patients (31%) reported post‐LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.