A Single Molecule Drug Targeting Photosensitizer for Enhanced Breast Cancer Photothermal Therapy. Issue 18 (19th April 2020)

• Record Type: Journal Article
• Authors: Zou, Yang; Li, Mingle; Xiong, Tao; Zhao, Xueze; Du, Jianjun; Fan, Jiangli; Peng, Xiaojun
• Is Part Of: Small. Volume 16:Issue 18(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-19
• Subjects: estrogen receptors -- photothermal therapy -- single molecule drug targeting -- structure‐inherent targeting; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201907677
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Targeting is one of the most important strategies for enhancing the efficacy of cancer photothermal therapy (PTT) and reducing damage to surrounding normal tissues. Compared with the traditional targeting approaches, the active targeting of breast cancer cells in PTT using chemotherapeutic drugs, such as tamoxifen (TAM), in combination with single‐molecule photothermal photosensitizers has superior selectivity and therapeutic effects. However, single‐molecule drug‐targeting photosensitizers for improved PTT efficacy are not widely reported. Accordingly, herein, a near‐infrared induced small‐molecule photothermal photosensitizer (CyT) is developed that actively targets the estrogen receptors (ERs) of breast cancer cells as well as targets mitochondria by structure‐inherent targeting. Cell uptake and cytotoxicity studies using different types of cells show that CyT enhances the efficiency of TAM‐based PTT by targeting ER‐overexpressing breast cancer cells and selectively killing them. In vivo experiments demonstrate that CyT can be used as a photothermal agent for fluorescence imaging‐guided PTT. More importantly, the intravenous injection of CyT results in better targeting and efficiency of tumor inhibition compared with that achieved with the TAM‐free control molecule Cy. Thus, the study presents an excellent small‐molecule photothermal agent for breast cancer therapy with potential clinical application prospects. Abstract : Cyanine dye small‐molecule organic photothermal photosensitizers with long‐wavelength absorption exhibit good synthetic flexibility and biocompatibility. Single molecule drug targeting photothermal photosensitizers that covalently connect to chemotherapeutic drug molecules represent a promising new strategy to improve the targeting ability of photothermal therapy (PTT). This manuscript focuses on designing and preparing targeting photosensitizer (CyT) for enhanced breast cancer PTT.