Catalytic Asymmetric Mannich‐Type Reaction of Malononitrile with N‐Boc α‐Ketiminoesters Using Chiral Organic Base Catalyst with Halogen Bond Donor Functionality. Issue 8 (13th March 2020)

• Record Type: Journal Article
• Authors: Kuwano, Satoru; Nishida, Yuki; Suzuki, Takumi; Arai, Takayoshi
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 8(2020)
• Page Start: 1674
• Page End: 1678
• Publication Date: 2020-03-13
• Subjects: Halogen bond -- Mannich-type reaction -- Unnatural amino acid -- α-Ketiminoester -- Iodine; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000092
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Chiral organic base catalyst with halogen bond donor functionality catalyzed asymmetric Mannich‐type reaction of malononitrile with α‐ketiminoesters to produce α, α‐disubstituted α‐amino acid derivatives in good yields with high enantioselectivities. The malononitrile‐derived amino acid was smoothly transformed to chiral aminomalonate without loss of ee. Abstract :