Transethnic genome‐wide scan identifies novel Alzheimer's disease loci. Issue 7 (7th February 2017)

• Record Type: Journal Article
• Authors: Jun, Gyungah R.; Chung, Jaeyoon; Mez, Jesse; Barber, Robert; Beecham, Gary W.; Bennett, David A.; Buxbaum, Joseph D.; Byrd, Goldie S.; Carrasquillo, Minerva M.; Crane, Paul K.; Cruchaga, Carlos; De Jager, Philip; Ertekin‐Taner, Nilufer; Evans, Denis; Fallin, M. Danielle; Foroud, Tatiana M.; Friedland, Robert P.; Goate, Alison M.; Graff‐Radford, Neill R.; Hendrie, Hugh; Hall, Kathleen S.; Hamilton‐Nelson, Kara L.; Inzelberg, Rivka; Kamboh, M. Ilyas; Kauwe, John S.K.; Kukull, Walter A.; Kunkle, Brian W.; Kuwano, Ryozo; Larson, Eric B.; Logue, Mark W.; Manly, Jennifer J.; Martin, Eden R.; Montine, Thomas J.; Mukherjee, Shubhabrata; Naj, Adam; Reiman, Eric M.; Reitz, Christiane; Sherva, Richard; St. George‐Hyslop, Peter H.; Thornton, Timothy; Younkin, Steven G.; Vardarajan, Badri N.; Wang, Li‐San; Wendlund, Jens R.; Winslow, Ashley R.; Adams, Perrie M.; Albert, Marilyn S.; Albin, Roger L.; Apostolova, Liana G.; Arnold, Steven E.; Asthana, Sanjay; Atwood, Craig S.; Barmada, Michjael M.; Barnes, Lisa L.; Beach, Thomas G.; Becker, James T.; Bigio, Eileen H.; Bird, Thomas D.; Blacker, Deborah; Boeve, Bradley F.; Bowen, James D.; Boxer, Adam; Burke, James R.; Cairns, Nigel J.; Cao, Chuanhai; Carlson, Chris S.; Carlsson, Cynthia M.; Carney, Regina M.; Carrasquillo, Minerva M.; Carroll, Steven L.; Chui, Helena C.; Clark, David G.; Corneveaux, Jason; Cribbs, David H.; Crocco, Elizabeth A.; Cruchaga, Carlos; De Jager, Philip L.; DeCarli, Charles; DeKosky, Steven T.; Demirci, F. Yesim; Dick, Malcolm; Dickson, Dennis W.; Doody, Rachelle S.; Duara, Ranjan; Ertekin‐Taner, Nilufer; Faber, Kelley M.; Fairchild, Thomas J.; Fallon, Kenneth B.; Farlow, Martin R.; Ferris, Steven; Frosch, Matthew P.; Galasko, Douglas R.; Gearing, Marla; Geschwind, Daniel H.; Ghetti, Bernardino; Gilbert, John R.; Glass, Jonathan D.; Graff‐Radford, Neill R.; Green, Robert C.; Growdon, John H.; Hakonarson, Hakon; Hamilton, Ronald L.; Hardy, John; Harrell, Lindy E.; Head, Elizabeth; Honig, Lawrence S.; Huebinger, Ryan M.; Huentelman, Matthew J.; Hulette, Christine M.; Hyman, Bradley T.; Jarvik, Gail P.; Jicha, Gregory A.; Jin, Lee‐Way; Karydas, Anna; Kauwe, John S.K.; Kaye, Jeffrey A.; Kim, Ronald; Koo, Edward H.; Kowall, Neil W.; Kramer, Joel H.; LaFerla, Frank M.; Lah, James J.; Leverenz, James B.; Levey, Allan I.; Li, Ge; Lieberman, Andrew P.; Lin, Chiao‐Feng; Lopez, Oscar L.; Lyketsos, Constantine G.; Mack, Wendy J.; Marson, Daniel C.; Martiniuk, Frank; Mash, Deborah C.; Masliah, Eliezer; McCormick, Wayne C.; McCurry, Susan M.; McDavid, Andrew N.; McKee, Ann C.; Mesulam, Marsel; Miller, Bruce L.; Miller, Carol A.; Miller, Joshua W.; Morris, John C.; Mukherjee, Shubhabrata; Murrell, Jill R.; Myers, Amanda J.; O'Bryant, Sid; Olichney, John M.; Pankratz, Vernon S.; Parisi, Joseph E.; Partch, Amanda; Paulson, Henry L.; Perry, William; Peskind, Elaine; Petersen, Ronald C.; Pierce, Aimee; Poon, Wayne W.; Potter, Huntington; Quinn, Joseph F.; Raj, Ashok; Raskind, Murray; Reisberg, Barry; Reisch, Joan S.; Reitz, Christiane; Ringman, John M.; Roberson, Erik D.; Rogaeva, Ekaterina; Rosen, Howard J.; Rosenberg, Roger N.; Royall, Donald R.; Sager, Mark A.; Sano, Mary; Saykin, Andrew J.; Schneider, Julie A.; Schneider, Lon S.; Seeley, William W.; Smith, Amanda G.; Sonnen, Joshua A.; Spina, Salvatore; Stern, Robert A.; Tanzi, Rudolph E.; Thornton‐Wells, Tricia A.; Trojanowski, John Q.; Troncoso, Juan C.; Tsuang, Debby W.; Van Deerlin, Vivianna M.; Van Eldik, Linda J.; Vardarajan, Badri N.; Vinters, Harry V.; Vonsattel, Jean Paul; Weintraub, Sandra; Welsh‐Bohmer, Kathleen A.; Williamson, Jennifer; Wishnek, Sarah; Woltjer, Randall L.; Wright, Clinton B.; Wu, Chuang‐Kuo; Yu, Chang‐En; Yu, Lei; Zhang, Xiaoling; Haines, Jonathan; Mayeux, Richard; Pericak‐Vance, Margaret A.; Schellenberg, Gerard; Lunetta, Kathryn L.; Farrer, Lindsay A.;
• Other Names: checker.
• Is Part Of: Alzheimer's & dementia. Volume 13:Issue 7(2017)
• Page Start: 727
• Page End: 738
• Publication Date: 2017-02-07
• Subjects: Transethnic -- Alzheimer's disease -- Genome‐wide association -- APOE interaction; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2016.12.012
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods: We conducted a transethnic genome‐wide association study (GWAS) for late‐onset AD in Stage 1 sample including whites of European Ancestry, African‐Americans, Japanese, and Israeli‐Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results: Genome‐wide significant (GWS) associations in single‐nucleotide polymorphism (SNP)–based tests ( P < 5 × 10 −8 ) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1‐AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence ( P < 2.7 × 10 −6 ) for gene‐based association in the total sample with a novel locus, TPBG ( P = 1.8 × 10 −6 ). Discussion: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.