Life‐course blood pressure in relation to brain volumes. Issue 8 (29th April 2016)

• Record Type: Journal Article
• Authors: Power, Melinda C.; Schneider, Andrea L.C.; Wruck, Lisa; Griswold, Michael; Coker, Laura H.; Alonso, Alvaro; Jack, Clifford R.; Knopman, David; Mosley, Thomas H.; Gottesman, Rebecca F.
• Is Part Of: Alzheimer's & dementia. Volume 12:Issue 8(2016)
• Page Start: 890
• Page End: 899
• Publication Date: 2016-04-29
• Subjects: Magnetic resonance imaging -- Brain volumes -- Neurodegeneration -- Alzheimer's disease -- Hypertension -- Blood pressure -- Hypotension -- Epidemiology -- Cohort study -- Human; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2016.03.012
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: The impact of blood pressure on brain volumes may be time‐dependent or pattern‐dependent. Methods: Of 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (∼24 or ∼15 years prior and concurrent with neuroimaging) with late life brain volumes. Results: Higher diastolic blood pressure ∼24 years prior, higher systolic and pulse pressure ∼15 years prior, and consistently elevated or rising systolic blood pressure from ∼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension ∼15 years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus: −0.27 standard units, 95% CI: −0.51, −0.03). Discussion: Hypertension 15 to 24 years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental.