Nonbreast cancer incidence, treatment received and outcomes: Are there differences in breast screening attendees versus nonattendees?. Issue 3 (2nd January 2020)

• Record Type: Journal Article
• Authors: Walpole, Euan; Dunn, Nathan; Youl, Philippa; Harden, Hazel; Furnival, Colin; Moore, Julie; Taylor, Kate; Evans, Elizabeth; Philpot, Shoni
• Is Part Of: International journal of cancer. Volume 147:Issue 3(2020)
• Page Start: 856
• Page End: 865
• Publication Date: 2020-01-02
• Subjects: screening -- breast neoplasms -- epidemiology -- mortality -- health literacy; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.32821
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : While reductions in breast cancer mortality have been evident since the introduction of population‐based breast screening in women aged 50–74 years, participation in cancer screening programs can be influenced by several factors, including health system and those related to the individual. In our study, we compared cancer incidence and mortality for several cancer types other than breast cancer, noncancer mortality and patterns of treatment amongst women who did and did not participate in mammography screening. All women aged 50–65 years enrolled on the Queensland Electoral Roll in 2000 were included. The study population was then linked to records from the population‐based breast screening program and private fee‐for‐service screening options to establish screened and unscreened cohorts. Diagnostic details for selected cancers and cause of death were obtained from the Queensland Oncology Repository. We calculated incidence rate ratios and hazard ratios comparing screened and unscreened cohorts. Among screened compared to unscreened women, we found a lower incidence of cancers of the lung, cervix, head and neck and esophagus and an increase in colorectal cancers. Cancer mortality (excluding breast cancer) was 35% lower among screened compared to unscreened women and they were also about 23% less likely to be diagnosed with distant disease. Screened compared to unscreened women were more likely to receive surgery and less likely to receive no treatment. Our study adds further to the population data examining outcomes among women participating in mammography screening. Abstract : What's new? Women whose breast cancers are detected via mammography screening are at reduced risk of breast cancer death. These women also experience reductions in overall cancer mortality, suggesting that mammography impacts outcomes of cancers other than breast cancer. In this population‐based study of women who did and did not undergo mammography screening, overall non‐breast cancer mortality was 35 percent lower among screened women. Incidence was reduced specifically for cancers of the cervix, esophagus, head and neck, and lungs, which frequently are associated with lifestyle behaviors. Screening further impacted early detection of non‐breast cancers, potentially facilitating treatment and improving outcome.