Detectable SARS‐CoV‐2 viral RNA in feces of three children during recovery period of COVID‐19 pneumonia. Issue 7 (15th April 2020)

• Record Type: Journal Article
• Authors: Zhang, Tongqiang; Cui, Xiaojian; Zhao, Xue; Wang, Jinhu; Zheng, Jiafeng; Zheng, Guifen; Guo, Wei; Cai, Chunquan; He, Sijia; Xu, Yongsheng
• Other Names: Luo Guangxiang (George) guestEditor.; Gao Shou‐Jiang guestEditor.
• Is Part Of: Journal of medical virology. Volume 92:Issue 7(2020)
• Page Start: 909
• Page End: 914
• Publication Date: 2020-04-15
• Subjects: children -- clinical characteristics -- COVID‐19 -- SARS‐CoV‐2; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.25795
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: Coronavirus Disease 2019 (COVID‐19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). After its first occurrence in Wuhan of China from December 2019, COVID‐19 rapidly spread around the world. According to the World Health Organization statement on 13 March 2020, there had been over 132 500 confirmed cases globally. Nevertheless, the case reports of children are rare, which results in the lack of evidence for preventing and controlling of children's infection. Here, we report three cases of SARS‐CoV‐2 infected children diagnosed from 3 February to 17 February 2020 in Tianjin, China. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. However, after been discharged, all three cases were tested SARS‐CoV‐2 positive in the stool samples within 10 days, in spite of their remained negative nucleic acid in throat swab specimens. Therefore, it is necessary to be aware of the possibility of fecal‐oral transmission of SARS‐CoV‐2 infection, especially for children cases. Highlights: Children with COVID‐19 are mostly mild cases and few severe cases have been reported. Here, we recruited three pediatric patients who experienced mild illness. After treatment, they all recovered soon with negative SARS‐CoV‐2 nucleic acid in throat swab specimens. However, after been discharged, all the three cases were tested SARS‐CoV‐2 positive in the fecal specimens within 10 days.