Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia. Issue 8 (4th April 2015)

• Record Type: Journal Article
• Authors: Sabbagh, Marwan N.; Chen, Kewei; Rogers, Joseph; Fleisher, Adam S.; Liebsack, Carolyn; Bandy, Dan; Belden, Christine; Protas, Hillary; Thiyyagura, Pradeep; Liu, Xiaofen; Roontiva, Auttawut; Luo, Ji; Jacobson, Sandra; Malek‐Ahmadi, Michael; Powell, Jessica; Reiman, Eric M.
• Is Part Of: Alzheimer's & dementia. Volume 11:Issue 8(2015)
• Page Start: 994
• Page End: 1004
• Publication Date: 2015-04-04
• Subjects: Down syndrome -- Florbetapir -- FDG‐PET -- PET -- Dementia -- Alzheimer's disease -- Imaging; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2015.01.006
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Down syndrome (DS) is associated with amyloid b (Ab) deposition. Methods: We characterized imaging measurements of regional fibrillar Ab burden, cerebral metabolic rate for glucose (rCMRgl), gray matter volumes (rGMVs), and age associations in 5 DS with dementia (DS/AD1), 12 DS without dementia (DS/AD2), and 9 normal controls (NCs). Results: There were significant group differences in mean standard uptake value ratios (SUVRs) for florbetapir with DS/AD1 having the highest, followed by DS/AD2, followed by NC. For [18F]‐fluorodeoxyglucose positron emission tomography, posterior cingulate rCMRgl in DS/AD1 was significantly reduced compared with DS/AD2 and NC. For volumetric magnetic resonance imaging (vMRI), hippocampal volumes were significantly reduced for the DS/AD1 compared with DS/AD2 and NC. Age‐related SUVR increases and rCMRgl reductions were greater in DS participants than in NCs. Discussion: DS is associated with fibrillar Ab, rCMRgl, and rGMV alterations in the dementia stage and before the presence of clinical decline. This study provides a foundation for the studies needed to inform treatment and prevention in DS.