Bifunctional Phosphonium Salt‐catalyzed Enantioselective [4+2] Annulation of Isoindigos with Allenes: Access to Complex Heterocycles with Centerpiece of 4H‐Pyrans. Issue 12 (17th April 2020)

• Record Type: Journal Article
• Authors: Du, Juan; Wu, Jia‐Hong; Zhu, Lixiang; Ren, Xiaoyu; Jiang, Chunhui; Wang, Tianli
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 12(2020)
• Page Start: 2510
• Page End: 2516
• Publication Date: 2020-04-17
• Subjects: complex heterocycles -- 4H-pyran derivatives -- [4+2] annulation -- bifunctional phosphonium salts -- H-bonding interaction; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000150
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Structurally fused heterocycles encompassing 4 H ‐pyran centerpiece are prevalent scaffolds with promising biological activities, but have daunting synthetic challenges. Herein, we presented a regio‐ and stereoselective [4+2] annulation of isoindigo derivatives with allenes by bifunctional phosphonium catalysis. This protocol provides a complementary way for accessing complex heterocyclic compounds. Abstract :