Delphi definition of the EADC‐ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. Issue 2 (14th August 2014)

• Record Type: Journal Article
• Authors: Boccardi, Marina; Bocchetta, Martina; Apostolova, Liana G.; Barnes, Josephine; Bartzokis, George; Corbetta, Gabriele; DeCarli, Charles; deToledo‐Morrell, Leyla; Firbank, Michael; Ganzola, Rossana; Gerritsen, Lotte; Henneman, Wouter; Killiany, Ronald J.; Malykhin, Nikolai; Pasqualetti, Patrizio; Pruessner, Jens C.; Redolfi, Alberto; Robitaille, Nicolas; Soininen, Hilkka; Tolomeo, Daniele; Wang, Lei; Watson, Craig; Wolf, Henrike; Duvernoy, Henri; Duchesne, Simon; Jack, Clifford R.; Frisoni, Giovanni B.
• Is Part Of: Alzheimer's & dementia. Volume 11:Issue 2(2015)
• Page Start: 126
• Page End: 138
• Publication Date: 2014-08-14
• Subjects: Hippocampus -- Atrophy -- Volumetry -- Manual segmentation -- Harmonization -- Anatomical landmarks -- Delphi procedure -- Alzheimer's disease -- Medial temporal lobe -- Hippocampal atrophy -- Magnetic resonance -- Neuroimaging -- Standard operational procedures -- Enrichment -- MCI -- Reliability; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2014.02.009
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Background: This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)‐based manual hippocampal segmentation. Methods: The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence‐based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results: Agreement was significant on the inclusion of alveus/fimbria ( P = .021), whole hippocampal tail ( P = .013), medial border of the body according to visible morphology ( P = .0006), and on this combined set of features ( P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer's disease‐related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter‐rater (0.94) estimates. Discussion: Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol.