Copper‐Catalyzed Direct Arylation of Indoles and Related (Hetero)arenes: A Ligandless and Solvent‐free Approach. Issue 12 (23rd April 2020)

• Record Type: Journal Article
• Authors: Pandey, Dilip K.; Shabade, Anand B.; Punji, Benudhar
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 12(2020)
• Page Start: 2534
• Page End: 2540
• Publication Date: 2020-04-23
• Subjects: Arylation -- C−H activation -- Chelation-assistance -- Copper -- Indole -- Solvent-free; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000312
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A ligandless and solvent‐free copper‐catalyzed method for the regioselective C−H bond arylation of indoles and related heteroarenes is reported. The use of CuCl efficiently catalyzes the direct coupling of diverse heteroarenes with aryl iodides via chelation‐assistance. This reaction could tolerate sensitive and structurally diverse functionalities, including halides, ethers, thioethers, amines, indolyl, pyrrolyl and carbazolyl groups. The directing group, 2‐pyridinyl can be smoothly removed to generate C‐2 arylated free‐ NH indoles, and the arylated indoles can further be functionalized into Tryptamine derivatives. Preliminary mechanistic study revealed a radical pathway for the arylation reaction. Abstract :