Feasibility, safety, and durability of porcine atrial ablation using a lattice‐tip temperature‐controlled radiofrequency ablation catheter. (17th April 2020)

• Record Type: Journal Article
• Authors: Koruth, Jacob S.; Kuroki, Kenji; Iwasawa, Jin; Batul, Syed A.; Turagam, Mohit K.; Dukkipati, Srinivas R.; Reddy, Vivek Y.
• Is Part Of: Journal of cardiovascular electrophysiology. Volume 31:Number 6(2020)
• Page Start: 1323
• Page End: 1331
• Publication Date: 2020-04-17
• Subjects: catheter ablation‐atrial fibrillation -- durable -- isolation -- isthmus -- pulmonary vein -- swine -- temperature; Blood vessels -- Physiology -- Periodicals; Electrophysiology -- Periodicals; Heart -- Physiology -- Periodicals; 612.1
• DOI: 10.1111/jce.14473
• Languages: English
• ISSNs: 1045-3873

Abstract

Abstract: Introduction: Pulmonary vein isolation (PVI) using standard radiofrequency (RF) catheters is limited by incomplete contiguity and prolonged procedural times. A novel, 9‐mm lattice‐tip irrigated RF catheter can create wide lesions rapidly in swine atria. Methods: In five swine, temperature limited (75°C) irrigated RF for 5 seconds/ablation was selected, to isolate seven pulmonary veins (PVs; five right superior and two inferior commons) and create five right atrial lines. After 4 weeks, repeat mapping and additional ablation to create atrial isthmus lesions were performed. The chronic lesions were submitted for histology. This was compared with right superior PVI data using standard 3.5‐mm irrigated tip ablation in six swine. Results: All targeted PVs (seven of seven, 100%) were acutely isolated. Durable isolation was observed in all six of six PVs treated with 5‐second applications, but not in one PV inadvertently treated with 4‐second applications. For the durably isolated PVs, the mean lesion count/PV and total RF time/PV was 16.3 ± 5.2 applications and 81.3 ± 25.9 seconds for the right superior and 14.5 ± 0.7 applications and 71.1 ± 5.5 seconds for the inferior common PV. Right atrial linear ablation was performed with a lesion count of 12 ± 2.3 applications and RF times of 59.5 ± 12.5 seconds. Cavotricuspid and mitral isthmus linear ablations were transmural along their entire length. All 53 of 53 (100%) sections were transmural on histology. Conclusion: Rapid and durable PVI and linear atrial ablation is feasible with this novel 9‐mm lattice‐tip catheter.