Immunization with neural‐derived peptides increases neurogenesis in rats with chronic spinal cord injury. (30th April 2020)

• Record Type: Journal Article
• Authors: Rodríguez‐Barrera, Roxana; Flores‐Romero, Adrián; García, Elisa; Fernández‐Presas, Ana Maria; Incontri‐Abraham, Diego; Navarro‐Torres, Lisset; García‐Sánchez, Julián; Juárez‐Vignon Whaley, Juan José; Madrazo, Ignacio; Ibarra, Antonio
• Other Names: Bailes Julian E. guestEditor.; Borlongan Cesar V. guestEditor.
• Is Part Of: CNS neuroscience & therapeutics. Volume 26:Number 6(2020)
• Page Start: 650
• Page End: 658
• Publication Date: 2020-04-30
• Subjects: A91 peptide -- INDP -- neurogenesis -- paraplegia -- protective autoimmunity -- SCI -- chronic stage -- motor recovery -- sensitive recovery -- protective autoimmunity -- traumatic brain injury; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13368
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Aims: Immunization with neural‐derived peptides (INDP) has demonstrated to be a promising therapy to achieve a regenerative effect in the chronic phase of the spinal cord injury (SCI). Nevertheless, INDP‐induced neurogenic effects in the chronic stage of SCI have not been explored. Methods and Results: In this study, we analyzed the effect of INDP on both motor and sensitive function recovery; afterward, we assessed neurogenesis and determined the production of cytokines (IL‐4, IL‐10, and TNF alpha) and neurotrophic factors (BDNF and GAP‐43). During the chronic stage of SCI, rats subjected to INDP showed a significant increase in both motor and sensitive recovery when compared to the control group. Moreover, we found a significant increase in neurogenesis, mainly at the central canal and at both the dorsal and ventral horns of INDP‐treated animals. Finally, INDP induced significant production of antiinflammatory and regeneration‐associated proteins in the chronic stages of SCI. Conclusions: These findings suggest that INDP has a neurogenic effect that could improve motor and sensitive recovery in the chronic stage of SCI. Moreover, our results also envision the use of INDP as a possible therapeutic strategy for other trauma‐related disorders like traumatic brain injury.