Cortical microstructural changes along the Alzheimer's disease continuum. Issue 3 (25th October 2017)

• Record Type: Journal Article
• Authors: Montal, Victor; Vilaplana, Eduard; Alcolea, Daniel; Pegueroles, Jordi; Pasternak, Ofer; González‐Ortiz, Sofia; Clarimón, Jordi; Carmona‐Iragui, María; Illán‐Gala, Ignacio; Morenas‐Rodríguez, Estrella; Ribosa‐Nogué, Roser; Sala, Isabel; Sánchez‐Saudinós, María‐Belén; García‐Sebastian, Maite; Villanúa, Jorge; Izagirre, Andrea; Estanga, Ainara; Ecay‐Torres, Mirian; Iriondo, Ane; Clerigue, Montserrat; Tainta, Mikel; Pozueta, Ana; González, Andrea; Martínez‐Heras, Eloy; Llufriu, Sara; Blesa, Rafael; Sanchez‐Juan, Pascual; Martínez‐Lage, Pablo; Lleó, Alberto; Fortea, Juan
• Is Part Of: Alzheimer's & dementia. Volume 14:Issue 3(2018)
• Page Start: 340
• Page End: 351
• Publication Date: 2017-10-25
• Subjects: Alzheimer's disease continuum -- MRI -- Cortical microstructure -- Biomarkers -- CSF -- Tau -- Amyloid; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2017.09.013
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum. Results: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages. Discussion: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification.