Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale. Issue 12 (10th July 2018)

• Record Type: Journal Article
• Authors: Navitsky, Michael; Joshi, Abhinay D.; Kennedy, Ian; Klunk, William E.; Rowe, Christopher C.; Wong, Dean F.; Pontecorvo, Michael J.; Mintun, Mark A.; Devous, Michael D.
• Is Part Of: Alzheimer's & dementia. Volume 14:Issue 12(2018)
• Page Start: 1565
• Page End: 1571
• Publication Date: 2018-07-10
• Subjects: Centiloids -- Florbetapir -- Pittsburgh compound B -- Amyloid imaging -- Standardization; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1016/j.jalz.2018.06.1353
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Methods: Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R 2 = 0.894) and Avid (R 2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. Results: The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVrAvid − 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy‐confirmed data is 24.1 Centiloids. Discussion: These findings may allow improved tracer‐independent amyloid quantitation.