Drug Delivery: Surfactant‐Stripped Cabazitaxel Micelles Stabilized by Clotrimazole or Mifepristone (Adv. Therap. 3/2020). Issue 3 (12th March 2020)

• Record Type: Journal Article
• Authors: Sun, Boyang; Chitgupi, Upendra; Li, Changning; Federizon, Jasmin; Zhang, Changjie; Ruszaj, Donna M.; Razi, Aida; Ortega, Joaquin; Neelamegham, Sriram; Zhang, Yumiao; Lovell, Jonathan F
• Is Part Of: Advanced therapeutics. Volume 3:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-12
• Subjects: Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202070007
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract : The cover image representing article number 1900161 by Jonathan F Lovell and co‐workers shows aggregates formed by the anti‐cancer drug cabazitaxel. In this work, it is shown that by co‐formulating cabazitaxel in unique surfactant micelles with certain other hydrophobic cargo, aggregation can be prevented, resulting in a potent chemotherapy formulation with long‐term liquid storage stability and a high drug‐to‐excipient ratio.