Xenon MRI: Functionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI (Adv. Biosys. 3/2020). Issue 3 (13th March 2020)

• Record Type: Journal Article
• Authors: Schnurr, Matthias; Volk, Ines; Nikolenko, Heike; Winkler, Lars; Dathe, Margitta; Schröder, Leif
• Is Part Of: Advanced biosystems. Volume 4:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-03-13
• Subjects: Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; Biological Science Disciplines; Periodicals; Periodicals; 660.6
• DOI: 10.1002/adbi.202070034
• Languages: English
• ISSNs: 2366-7478

Abstract

Abstract : In article number 1900251, Margitta Dathe, Leif Schröder, and co‐workers demonstrate an MRI contrast agent that uses the available magnetization in a highly efficient way to enable selective cell labelling at minimally invasive concentrations. The micelle approach for 129Xe HyperCEST imaging provides highly efficient depolarization points to impact hyperpolarized spin ensembles and yield a switchable image contrast with a highly reduced labelling volume of target cells. Illustration credits: Barth van Rossum, FMP.