Multiclass and multiresidue screening of veterinary drugs and pesticides in infant formula using Quadrupole‐Orbitrap MS with PRM scan mode. (8th February 2020)

• Record Type: Journal Article
• Authors: Zhang, Lu‐Qi; Zhang, Xiao‐Mei; Zhang, Hong‐Wei; Wang, Hui; Xu, Hui; Wang, Feng‐Mei; Lin, Chao; Xiao, Jing; Xu, Wen‐Yuan
• Is Part Of: Journal of mass spectrometry. Volume 55:Number 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-08
• Subjects: infant formula -- multiclass residues -- Orbitrap -- PRM -- screening; Mass spectrometry -- Periodicals; 543.65
• DOI: 10.1002/jms.4497
• Languages: English
• ISSNs: 1076-5174

Abstract

Abstract: A multiclass and multiresidue method for screening veterinary drugs and pesticides in infant formula was developed and validated using ultrahigh‐performance liquid chromatography coupled to Quadrupole‐Orbitrap high‐resolution mass spectrometry (UHPLC‐HRMS). A total of 49 veterinary drugs and pesticides investigated belong to 11 classes including antivirals, anticoccidials, macrolides, pyrethroids, insecticides, sulfonamides, beta‐agonists, sedatives, thyreostats, nonsteroidal anti‐inflammatory drugs, and other pharmacologically active substances. A generic sample preparation and highly selective acquisition mode of parallel reaction monitoring (PRM) were deliberately incorporated to perform efficient screening analysis. As a result, the screening target concentrations of the analytes varied from 1 to 500 μg/kg with ≤5% of false compliant rate as specified in Decision 2002/657/EC for screening analysis. The average recoveries ranged from 40.7 to 124.9% as well as the relative standard deviations from 4.2 to 26.6%, respectively. The matrix effects and interferences were effectively controlled by integrated application of dispersive solid phase extraction, PRM scan mode, and matrix‐matched standard calibration. The proposed method will be helpful to provide applicable strategy for screening residues in infant formula with surveillance purpose.