MRI cine‐tagging of cardiac‐induced motion for noninvasive staging of liver fibrosis. Issue 5 (12th October 2019)

• Record Type: Journal Article
• Authors: Lefebvre, Thierry; Petitclerc, Léonie; Hébert, Mélanie; Bilodeau, Laurent; Sebastiani, Giada; Olivié, Damien; Gao, Zu‐Hua; Sylvestre, Marie‐Pierre; Cloutier, Guy; Nguyen, Bich N.; Gilbert, Guillaume; Tang, An
• Is Part Of: Journal of magnetic resonance imaging. Volume 51:Issue 5(2020)
• Page Start: 1570
• Page End: 1580
• Publication Date: 2019-10-12
• Subjects: liver fibrosis staging -- quantitative imaging biomarker -- chronic liver disease -- liver biopsy -- MRI cine‐tagging -- strain; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.26935
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Background: MR elastography is a noninvasive technique that provides high diagnostic accuracy for the staging of liver fibrosis; however, it requires external hardware and mainly assesses the right lobe. Purpose: To evaluate the diagnostic performance of MRI cine‐tagging for staging fibrosis in the left liver lobe, using biopsy as the reference standard. Study Type: Institutional Review Board (IRB)‐approved two‐center prospective study. Population: Seventy‐six patients with chronic liver disease who underwent an MRI cine‐tagging examination and a liver biopsy within a 6‐week interval. Field Strength/Sequence: 2D‐GRE multislice sequence at 3.0T with spatial modulation of the magnetization preparation sequence and peripheral pulse‐wave triggering on two coronal slices chosen underneath the heart apex to capture maximal deformation with consecutive breath‐holds adapted to patient cardiac frequency. Assessment: A region of interest was selected in the liver close to the heart apex. Maximal strain was evaluated with the harmonic phase (HARP) technique. Statistical Tests: Spearman's correlation, Kruskal–Wallis test, Mann–Whitney U ‐test, and receiver operating characteristic (ROC) analysis were performed. Results: Liver strain measured on tagged images decreased with higher histological fibrosis stage ( ρ = –0.68, P < 0.0001). Strain values were significantly different between all fibrosis stages ( P < 0.0001), and between groups of fibrosis stages ≤F3 vs. F4 ( P < 0.05). Areas under the ROC curves were 0.95 (95% confidence interval: 0.89–1.00) to distinguish fibrosis stages F0 vs. F4, 0.81 (0.70–0.92) for stages F0 vs. ≥F1, 0.84 (0.76–0.93) for stages ≤F1 vs. ≥F2, 0.86 (0.78–0.94) for stages ≤F2 vs. ≥F3, and 0.87 (0.77–0.96) for stages ≤F3 vs. F4. Data Conclusion: MRI cine‐tagging is a promising technique for measuring liver strain without additional elastography hardware. It could be used to assess the left liver lobe as a complement to current techniques assessing the right lobe. Level of Evidence: 1 Technical Efficacy: 3 J. Magn. Reson. Imaging 2020;51:1570–1580.