Conjugation of pectin biopolymer with Au‐nanoparticles as a drug delivery system: Experimental and DFT studies. (21st February 2020)

• Record Type: Journal Article
• Authors: Khodashenas, Bahareh; Ardjmand, Mehdi; Baei, Mazyar Sharifzadeh; Rad, Ali Shokuhi; Akbarzadeh, Azim
• Is Part Of: Applied organometallic chemistry. Volume 34:Number 6(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-21
• Subjects: biopolymer -- curcumin -- drug delivery systems -- gold nanoparticle -- pectin; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.5609
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : In the present study, pectin‐coated gold nanoparticles (GNPs) were used as a candidate for curcumin drug delivery. The effect of the size of synthesized GNPs was examined, as an important factor on the yield of drug delivery. For this purpose, three different sizes of GNPs were first synthesized using a chemical method. The synthesized nanoparticles were then coated with pectin biopolymer. Finally, curcumin drug was loaded in a pectin@GNPs complex. Various methods such as UV–vis spectrophotometry, dynamic light scattering, scanning electron microscopy and Fourier‐transform infrared spectroscopy were used to characterize the synthesized GNPs and pectin@GNPs. The encapsulation efficiency and the release percentage of the drug were calculated for two different pH values. Further, an antibacterial study was conducted. The results revealed that 100 nm GNPs had the highest encapsulation efficiency. An investigation of the release rate of curcumin drug at 37°C for 48 h indicated that the amount of drug released was higher in acidic pH than at pH 7.4 with a slow release rate. The electronic structure and the adsorption properties of pectin–GNPs complex were examined using the density functional theory method. Abstract : *Pectin coated Gold nanoparticles(GNPs) were used as a candidate for curcumindrug delivery.*The release amount of drug in theacidic pH was higher than pH 7.4 with the slow release rate.*It has been shown that the size of NPs have a little influence onthe encapsulation efficiency of complexes.