Gadolinium–Rose Bengal Coordination Polymer Nanodots for MR‐/Fluorescence‐Image‐Guided Radiation and Photodynamic Therapy. Issue 23 (4th May 2020)

• Record Type: Journal Article
• Authors: Sun, Wenjing; Luo, Li; Feng, Yushuo; Qiu, Yuwei; Shi, Changrong; Meng, Shanshan; Chen, Xiaoyuan; Chen, Hongmin
• Is Part Of: Advanced materials. Volume 32:Issue 23(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-04
• Subjects: coordination polymer nanodots -- enhanced fluorescence -- magnetic resonance imaging -- nanotheranostics -- photodynamic therapy -- radiotherapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202000377
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Combination therapy based on nanomedicine has gained momentum in oncology in recent years, offering superior safety and efficacy over monotherapies. It is critical to design theranostics that are composed of imaging and therapeutic agents already approved. Herein, gadolinium (Gd)–rose bengal coordination polymer nanodots (GRDs) are reported. The GRDs exhibit a unique absorption property and 7.7‐fold luminescence enhancement, as well as a 1.9‐fold increase in singlet oxygen generation efficiency over free rose bengal. Meanwhile, GRDs exhibit a twofold increase in r 1 relaxivity over gadopentetic acid (Gd‐DTPA) and have better X‐ray absorption ability than rose bengal alone. These excellent properties of the GRDs are verified both in vitro and in vivo. The combination of photodynamic therapy (PDT) and radiation therapy (RT) more significantly inhibits tumor growth than monotherapies (i.e., PDT or RT). This work offers a new route to designing and synthesizing Gd‐based nanotheranostics for image‐guided cancer therapy. Abstract : Gadolinium–rose bengal coordination polymer nanodots exhibit enhanced dual‐modal imaging, as well as significant increase of singlet oxygen generation and radiosensitization over free rose bengal. In vitro and in vivo investigations demonstrate that the combination of photodynamic therapy (PDT) and radiation therapy (RT) more significantly inhibits tumor growth than monotherapies (i.e., PDT or RT).