Fabrication of Copper‐based Silica‐coated Magnetic Nanocatalyst for Efficient One‐pot Synthesis of Chalcones via A3 Coupling of Aldehydes‐Alkynes‐Amines. Issue 9 (23rd March 2020)

• Record Type: Journal Article
• Authors: Yadav, Priya; Yadav, Manavi; Gaur, Rashmi; Gupta, Radhika; Arora, Gunjan; Rana, Pooja; Srivastava, Anju; Sharma, Rakesh K.
• Is Part Of: ChemCatChem. Volume 12:Issue 9(2020)
• Page Start: 2488
• Page End: 2496
• Publication Date: 2020-03-23
• Subjects: magnetic nanocatalyst -- chalcones -- A3 Coupling -- one-pot synthesis -- solvent-less synthesis; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.202000148
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica‐coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility for the solvent‐free one‐pot synthesis of chalcone moieties by A 3 coupling of aldehydes‐alkynes‐amines in good to excellent yields. The fabricated Cu@DBM@ASMNPs was structurally and chemically analyzed by various techniques such as FT‐IR, SEM, TEM, VSM, ICP‐MS, ED‐XRF and XPS. The programmed catalytic protocol has been proceeded via isomerization‐hydrolysis reaction of aldehydes and terminal alkynes. The present strategy offered much greener and efficacious synthesis of chalcones by adding benefits such as solvent‐less synthetic protocol and much shorter reaction time. Other interesting and noteworthy features of this methodology are broad substrate scope, mild reaction conditions, and reusability up to seven runs without significant loss of its catalytic activity which renders it an environmentally friendly and remarkable protocol from industrial point of view. Abstract : Chef Copper in the kitchen : Highly proficient copper based magnetically retrievable nanocatalyst was synthesized, characterized and further utilized for A 3 coupling of aldehydes‐alkynes‐amines for the one pot synthesis of chalcones under solvent free conditions