Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease. Issue 5 (5th February 2020)

• Record Type: Journal Article
• Authors: Andica, Christina; Kamagata, Koji; Hatano, Taku; Saito, Yuya; Uchida, Wataru; Ogawa, Takashi; Takeshige‐Amano, Haruka; Hagiwara, Akifumi; Murata, Syo; Oyama, Genko; Shimo, Yashushi; Umemura, Atsushi; Akashi, Toshiaki; Wada, Akihiko; Kumamaru, Kanako K.; Hori, Masaaki; Hattori, Nobutaka; Aoki, Shigeki
• Is Part Of: Journal of neuroscience research. Volume 98:Issue 5(2020)
• Page Start: 936
• Page End: 949
• Publication Date: 2020-02-05
• Subjects: axons -- biomarkers -- diffusion tensor imaging -- linked independent component analysis -- neurite orientation dispersion and density imaging -- Parkinson's disease; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.24584
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract: Neurocognitive and psychiatric disorders have significant consequences for quality of life in patients with Parkinson's disease (PD). In the current study, we evaluated microstructural white matter (WM) alterations associated with neurocognitive and psychiatric disorders in PD using neurite orientation dispersion and density imaging (NODDI) and linked independent component analysis (LICA). The indices of NODDI were compared between 20 and 19 patients with PD with and without neurocognitive and psychiatric disorders, respectively, and 25 healthy controls using tract‐based spatial statistics and tract‐of‐interest analyses. LICA was applied to model inter‐subject variability across measures. A widespread reduction in axonal density (indexed by intracellular volume fraction [ICVF]) was demonstrated in PD patients with and without neurocognitive and psychiatric disorders, as compared with healthy controls. Compared with patients without neurocognitive and psychiatric disorders, patients with neurocognitive and psychiatric disorders exhibited more extensive (posterior predominant) decreases in axonal density. Using LICA, ICVF demonstrated the highest contribution (59% weight) to the main effects of diagnosis that reflected widespread decreases in axonal density. These findings suggest that axonal loss is a major factor underlying WM pathology related to neurocognitive and psychiatric disorders in PD, whereas patients with neurocognitive and psychiatric disorders had broader axonal pathology, as compared with those without. LICA suggested that the ICVF can be used as a useful biomarker of microstructural changes in the WM related to neurocognitive and psychiatric disorders in PD. Abstract : This study demonstrates that axonal loss, indicated by a reduction in the intracellular volume fraction, is a major factor underlying white matter pathology related to neurocognitive and psychiatric disorders in Parkinson's disease. Furthermore, patients with neurocognitive and psychiatric disorders had broader axonal pathology (posterior predominant) compared with those without such disorders.