Multi‐Caged IrOx for Facile Preparation of "Six‐in‐One" Nanoagent for Subcutaneous and Lymphatic Tumors Inhibition against Recurrence and Metastasis. (30th April 2020)

• Record Type: Journal Article
• Authors: Zhen, Wenyao; Liu, Yang; Zhang, Mengchao; Hu, Wenxue; Wang, Wei; Jia, Xiaodan; Jiang, Xiue
• Is Part Of: Advanced functional materials. Volume 30:Number 24(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-30
• Subjects: iridium oxide -- multi‐model imaging -- nanocarriers -- sono‐photodynamic therapy -- tumor metastasis; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202002274
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Single nanocarriers with intrinsic characteristics of diagnosis, effective therapy against solid malignancies with fatal metastasis, and tumor microenvironment regulation are promising in construction of a simple and effective multimode nanotheranostic system. Herein, multi‐caged IrO x nanocarriers are fabricated by direct thermal hydrolysis strategy, which exhibit good sono‐photodynamic response, outstanding gemstone spectral computed tomography, and photoacoustic (PA) imaging capabilities, universal loading, and pinpoint drug release properties. As a proof of concept, a gemstone spectral computed tomography/PA/fluorescence imaging–guided oxygen self‐sufficient sono‐photo‐chemotherapy nanoagent by simple loading of doxorubicin is constructed. The remarkable synergistic therapy and excellent hypoxia releasing capabilities can remove both subcutaneous and sentinel lymph nodes metastasis tumors, and effectively suppress tumor recurrence and lung metastasis, thus greatly prolonging survival time. The study provides an attractive candidate to construct a "six‐in‐one" (tri‐modal therapies and three imaging modalities) tumor theranostic system. Abstract : Herein, multifunctional IrO x nanocarriers are fabricated, which effectively load doxorubicin and realize gemstone spectral computed tomography/photoacoustic/fluorescence imaging–guided oxygen self‐sufficient tumor sono‐photo‐chemotherapy. The synergistic therapies at a relative low dose can completely remove both of subcutaneous tumors and sentinel lymph nodes metastasis tumors, and effectively suppress tumor recurrence and lung metastasis, thus greatly prolonging survival time.