Mesoporous Silica Particles: Entrapping Digestive Enzymes with Engineered Mesoporous Silica Particles Reduces Metabolic Risk Factors in Humans (Adv. Healthcare Mater. 11/2020). Issue 11 (10th June 2020)

• Record Type: Journal Article
• Authors: Waara, Erik R.; Iqbal, Muhammad N.; Robert‐Nicoud, Ghislaine; Benziane, Boubacar; Vallhov, Helen; Wasik, Agata M.; Lindgren, Maria; Hagman, Emilia; Rinde, Mia; Kupferschmidt, Natalia; Berlin, Roger; Johnston, Eric V.; Danielsson, Pernilla; Bengtsson, Tore
• Is Part Of: Advanced healthcare materials. Volume 9:Issue 11(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-10
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202070033
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article number 202000057, Tore Bengtsson and co‐workers report that oral intake of mesoporous silica particles (MSP) reduce glycated hemoglobin and low‐density lipoprotein in healthy individuals with obesity. Preclinical investigations show sequestration of pancreatic a‐amylase and lipase by MSP, suggesting that MSP lowers digestive enzymes availability in the small intestine, resulting in decreased digestion of macronutrients and reduced caloric uptake.