Green biosynthesis of gold nanoparticles using Croton sparsiflorus leaves extract and evaluation of UV protection, antibacterial and anticancer applications. (13th February 2020) - Boomi, Pandi
Abstract : Our study reports greener synthesis of gold nanoparticles (AuNPs) tethered to the extract of Croton sparsiflorus and in vitro evaluation of UV‐protection, antibacterial and anticancer activities. Sophisticated instrumental analytical techniques such as UV–vis spectrophotometer, FT‐IR, XRD, FE‐SEM, and TEM were employed for the existence and confirmation of the nanoparticles. FT‐IR and HPLC analysis were executed in the identification of the plausible functional groups implicated in the reduction of gold ions to AuNPs. UV protection property and antibacterial action of AuNPs‐coated cotton fabric were also presented. Moreover, in vitro anticancer evaluation against HepG2 cell line was conducted by MTT assay for Croton sparsiflorus extract derived AuNPs in different concentrations (50 to 150 μg/ml). Thus, the results of this work revealed that greener synthesized AuNPs exhibited good therapeutic applications as UV‐protection, antibacterial and anticancer agents. Abstract : AuNPs nanoparticles was synthesized using Croton sparsiflorus leaves extract by stirrer method and characterized. Improved UV protection property and antibacterial activity of AuNPs‐coated cotton fabric were evaluated. Improved anticancer activity against HepG2 cell line was also reported.