Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF‐κB/MAPK signaling pathway. (12th November 2019)

• Record Type: Journal Article
• Authors: Huang, Yuntai; Guo, Lubo; Chitti, Renukaradhya; Sreeharsha, Nagaraja; Mishra, Anurag; Gubbiyappa, Shiva K.; Singh, Yogendra
• Other Names: Korac Bato guestEditor.; Galli Francesco guestEditor.
• Is Part Of: BioFactors. Volume 46:Number 2(2020)
• Page Start: 283
• Page End: 291
• Publication Date: 2019-11-12
• Subjects: complete Freund's adjuvant -- indomethacin -- MAPK -- NF‐κB -- rheumatoid arthritis -- wogonin; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1585
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Rheumatoid arthritis (RA) is a chronic and accelerated autoimmune illness with proliferative and damaging synovitis, resulting in joint death and cartilage and bone erosion. This study focused on the potential therapeutic effect of wogonin on complete Freund's adjuvant (CFA) induced RA in rats and the underlying mechanisms. Arthritis was experimentally caused in rats by subcutaneously injecting 0.1 mL of CFA into the subplantar area of the left hind paw under moderate anesthesia on day zero. The regular oral doses of indomethacin/wogonin began on day zero and proceeded after injection to day 35. Wogonin reduced arthritic score considerably, enhanced body weight, and reduced paw thickness. Wogonin also boosted red blood cell considerably along with hemoglobin and reduced white blood cell count and erythrocyte sedimentation rate. Wogonin substantially improved an altered level of oxidative stress markers, antioxidant proteins, and inflammatory cytokines in a dose‐dependent way. Wogonin inhibited p38 phosphorylation triggered by CFA and p65 nuclear translocation.