Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice. Issue 6 (5th February 2020)

• Record Type: Journal Article
• Authors: Lin, Kuan‐Ho; Marthandam Asokan, Shibu; Kuo, Wei‐Wen; Hsieh, You‐Liang; Lii, Chong‐Kuei; Viswanadha, Vijayapadma; Lin, Yi‐Lin; Wang, Shulin; Yang, Caixian; Huang, Chih‐Yang
• Is Part Of: Environmental toxicology. Volume 35:Issue 6(2020)
• Page Start: 707
• Page End: 713
• Publication Date: 2020-02-05
• Subjects: Andrographis paniculata -- cardiac apoptosis -- cell survival -- high fat diet -- obesity; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.22906
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases . In this study, an active metabolite andrographolide from Andrographis paniculata was found to ameliorate HFD‐induced cardiac apoptosis. C57/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25 mg/kg/d) andrographolide treatment (n = 9), and high dose (50 mg/kg/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac‐damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro‐apoptotic proteins and decrease in the proteins of IGF‐1R‐survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.