Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications. Issue 4 (6th September 2019)

• Record Type: Journal Article
• Authors: Frey, Benjamin S.; Damon, Deidre E.; Badu‐Tawiah, Abraham K.
• Is Part Of: Mass spectrometry reviews. Volume 39:Issue 4(2020)
• Page Start: 336
• Page End: 370
• Publication Date: 2019-09-06
• Subjects: microsampling -- dried blood spot (DBS) -- paper spray (PS) -- ambient ionization -- direct analysis -- mass spectrometry -- solid‐phase extraction -- microfluidic devices -- direct reaction monitoring by paper spray; Mass spectrometry -- Periodicals; 543
• DOI: 10.1002/mas.21601
• Languages: English
• ISSNs: 0277-7037

Abstract

Abstract : Recent advancements in the sensitivity of chemical instrumentation have led to increased interest in the use of microsamples for translational and biomedical research. Paper substrates are by far the most widely used media for biofluid collection, and mass spectrometry is the preferred method of analysis of the resultant dried blood spot (DBS) samples. Although there have been a variety of review papers published on DBS, there has been no attempt to unify the century old DBS methodology with modern applications utilizing modified paper and paper‐based microfluidics for sampling, storage, processing, and analysis. This critical review will discuss how mass spectrometry has expanded the utility of paper substrates from sample collection and storage, to direct complex mixture analysis to on‐surface reaction monitoring.