A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy. Issue 22 (24th April 2020)

• Record Type: Journal Article
• Authors: Wang, Jinping; Sun, Jingyu; Hu, Wei; Wang, Yuhao; Chou, Tsengming; Zhang, Beilu; Zhang, Qiang; Ren, Lei; Wang, Hongjun
• Is Part Of: Advanced materials. Volume 32:Issue 22(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-24
• Subjects: bimetallic Rh‐based core–shell nanostructures -- bimodal imaging -- endogenous oxygenation -- enhanced photodynamic therapy -- hypoxia alleviation; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202001862
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: In treatment of hypoxic tumors, oxygen‐dependent photodynamic therapy (PDT) is considerably limited. Herein, a new bimetallic and biphasic Rh‐based core–shell nanosystem (Au@Rh‐ICG‐CM) is developed to address tumor hypoxia while achieving high PDT efficacy. Such porous Au@Rh core–shell nanostructures are expected to exhibit catalase‐like activity to efficiently catalyze oxygen generation from endogenous hydrogen peroxide in tumors. Coating Au@Rh nanostructures with tumor cell membrane (CM) enables tumor targeting via homologous binding. As a result of the large pores of Rh shells and the trapping ability of CM, the photosensitizer indocyanine green (ICG) is successfully loaded and retained in the cavity of Au@Rh‐CM. Au@Rh‐ICG‐CM shows good biocompatibility, high tumor accumulation, and superior fluorescence and photoacoustic imaging properties. Both in vitro and in vivo results demonstrate that Au@Rh‐ICG‐CM is able to effectively convert endogenous hydrogen peroxide into oxygen and then elevate the production of tumor‐toxic singlet oxygen to significantly enhance PDT. As noted, the mild photothermal effect of Au@Rh‐ICG‐CM also improves PDT efficacy. By integrating the superiorities of hypoxia regulation function, tumor accumulation capacity, bimodal imaging, and moderate photothermal effect into a single nanosystem, Au@Rh‐ICG‐CM can readily serve as a promising nanoplatform for enhanced cancer PDT. Abstract : In treatment of hypoxic tumors, oxygen‐dependent photodynamic therapy (PDT) is considerably limited. In this work, a new bimetallic and biphasic Rh‐based core–shell nanosystem (Au@Rh‐indocyanine green‐cell membrane) is developed. Such porous Au@Rh core–shell nanostructures exhibit catalase‐like activity to efficiently catalyze oxygen generation from endogenous hydrogen peroxide to address tumor hypoxia while achieving high PDT efficacy.