Conjunctival microcirculation is associated with cerebral cortex microcirculation in post‐resuscitation mild hypothermia: A rat model. (5th February 2020)

• Record Type: Journal Article
• Authors: Zhao, Shen; Yang, Zhengfei; Sun, Peng; Wu, Xiaobo; Tang, Wanchun; Shao, Fei; Tang, Ziren
• Is Part Of: Microcirculation. Volume 27:Number 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-05
• Subjects: cardiac arrest -- cerebral cortex microcirculation -- conjunctival microcirculation -- mild hypothermia -- restoration of spontaneous circulation; Biological transport -- Periodicals; Microcirculation -- Physiology -- Periodicals; 612.135
• DOI: 10.1111/micc.12604
• Languages: English
• ISSNs: 1073-9688

Abstract

Abstract: Objective: This study aimed to compare the changes in sublingual and conjunctival microcirculation occurring with cerebral cortex microcirculation changes during mild hypothermia in a rat model of cardiac arrest. Methods: Twenty‐four rats were randomized into mild hypothermia (M) or normothermia (C) groups. Ventricular fibrillation was electrically induced and left untreated for 8 minutes, followed by 8 minutes of cardiopulmonary resuscitation. The core temperature in group M reduced to 33 ± 0.5°C at 13 minutes after restoration of spontaneous circulation and was maintained for 8 hours. In group C, the core temperature was maintained at 37 ± 0.2°C. The hemodynamics and microcirculation in the sublingual region, bulbar conjunctiva, and cerebral cortex were measured at baseline and 1, 2, 3, 4, 6, and 8 hours after restoration of spontaneous circulation. Results: The M group showed significantly worse sublingual microcirculation at 6 hours post‐resuscitation. However, microcirculation in the conjunctiva and cerebral cortex at 3 hours post‐resuscitation were better in the M group. In the M group, microcirculation in the cerebral cortex was significantly correlated with that in the conjunctiva but not the sublingual microcirculation. Conclusions: Changes in conjunctival microcirculation are closely related to cerebral cortex microcirculation during mild hypothermia, indicating that cerebral cortex microcirculation could be monitored by measuring conjunctival microcirculation.