Redox control of vascular biology. (4th September 2019)

• Record Type: Journal Article
• Authors: Obradovic, Milan; Essack, Magbubah; Zafirovic, Sonja; Sudar‐Milovanovic, Emina; Bajic, Vladan P.; Van Neste, Christophe; Trpkovic, Andreja; Stanimirovic, Julijana; Bajic, Vladimir B.; Isenovic, Esma R.
• Other Names: Korac Bato guestEditor.; Galli Francesco guestEditor.
• Is Part Of: BioFactors. Volume 46:Number 2(2020)
• Page Start: 246
• Page End: 262
• Publication Date: 2019-09-04
• Subjects: cardiovascular diseases -- cardiovascular system -- reactive oxygen species -- redox; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1559
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic‐specific knowledgebase DES‐RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology.