Evaluating body composition in infancy and childhood: A comparison between 4C, QMR, DXA, and ADP. Issue 6 (27th January 2020) - Heard‐Lipsmeyer, Melissa E.
Summary: Background: Accurate and precise methods to measure of body composition in infancy and childhood are needed. Objectives: This study evaluated differences and precision of three methods when compared with the four‐compartment (4C) model for estimating fat mass (FM). Methods: FM of children (age 14 days to 6 years of age, N = 346) was obtained using quantitative nuclear magnetic resonance (QMR, EchoMRI‐AH), air‐displacement plethysmography (ADP, PeaPod, less than or equal to 8 kg, BodPod age 6 years or older), and dual‐energy X‐ray absorptiometry (DXA, Hologic QDR). The 4C model was computed. Correlation, concordance, and Bland‐Altman analyses were performed. Results: In infants, PeaPod had high individual FM accuracy, whereas DXA had high group FM accuracy compared with 4C. In children, DXA had high group and individual FM accuracies compared with 4C. QMR underestimated group FM in infants and children (300 and 510 g, respectively). The instrument FM precision was best for QMR (10 g) followed by BodPod (34 g), PeaPod (38 g), and DXA (45 g). Conclusions: In infants, PeaPod was the best method to estimate individual FM whereas DXA was best to estimate group FM. In children, DXA was best to estimate individual and group FM. QMR had the highest instrument precision.