Front Cover: A Smart Nanotherapeutic Agent for in vitro and in vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy (ChemMedChem 5/2020). (5th March 2020)

• Record Type: Journal Article
• Authors: Adhikari, Aniruddha; Biswas, Pritam; Mondal, Susmita; Das, Monojit; Darbar, Soumendra; Hameed, Ahmed M.; Alharbi, Ahmed; Ahmed, Saleh A.; Sankar Bhattacharya, Siddhartha; Pal, Debasish; Kumar Pal, Samir
• Is Part Of: ChemMedChem. Volume 15:Number 5(2020)
• Page Start: 391
• Page End: 391
• Publication Date: 2020-03-05
• Subjects: Heavy metal toxicity -- Nanomedicine -- Surface functionalized Mn3O4 nanoparticles -- Chelation -- Lead toxicity; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202000098
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The Front Cover shows the efficacy of a nanohybrid containing covalently attached citrate functionalized Mn3 O4 nanoparticles (nanomedicine) for remediation of heavy metal toxicity due to environmental pollution and reckless lifestyle. The nanomedicine chelates the heavy metal and removes it from the body, simultaneously scavenging the oxidative stress generated by the toxicity. While a detailed in vitro spectroscopic study for the heavy metal chelation and ROS scavenging reveals microscopic understanding, a comprehensive in vivo experiment on mice models confirms the efficacy of the nanomedicine in animals. (Featured illustration by Aniruddha Adhikari.) More information can be found in the Full Paper by Samir Kumar Pal et al. on page 420 in Issue 5, 2020 (DOI: 10.1002/cmdc.201900543 ).