Acculturation and selected birth defects among non‐Hispanic Blacks in a population‐based case–control study. Issue 7 (5th March 2020)

• Record Type: Journal Article
• Authors: Hoyt, Adrienne T.; Ramadhani, Tunu; Le, Mimi T.; Shumate, Charlie J.; Canfield, Mark A.; Scheuerle, Angela E.
• Is Part Of: Birth defects research. Volume 112:Issue 7(2020)
• Page Start: 535
• Page End: 554
• Publication Date: 2020-03-05
• Subjects: acculturation -- Africans -- birth defects -- congenital defects -- congenital heart defects -- malformations -- nativity -- non‐Hispanic Blacks; Teratology -- Periodicals; Abnormalities, Human -- Periodicals; Congenital Abnormalities; Embryo, Mammalian -- abnormalities; Teratology; Abnormalities, Human; Teratology; Periodicals; Periodicals; 616.043
• DOI: 10.1002/bdr2.1665
• Languages: English
• ISSNs: 2472-1727

Abstract

Abstract: Background: There are noted birth defects prevalence differences between race/ethnicity groups. For instance, non‐Hispanic (NH) Black mothers are more likely to have an infant with encephalocele, although less likely to have an infant with anotia/microtia compared to NH Whites. When stratifying by nativity and years lived within the United States, additional variations become apparent. Methods: Data from the National Birth Defects Prevention Study were used to calculate descriptive statistics and estimate crude/adjusted odds ratios (aORs) and 95% confidence intervals (95%CIs) among NH Blacks with one of 30 major defects and non‐malformed controls. Total case/controls were as follows: U.S.‐ (2, 773/1101); Foreign‐ (343/151); African‐born (161/64). Study participants were also examined by number of years lived in the U.S. (≤5 vs. 6+ years). Results: Compared to U.S.‐born, foreign‐born NH Black controls tended to be older, had more years of education, and were more likely to have a higher household income. They also had fewer previous livebirths and were less likely to be obese. In the adjusted analyses, two defect groups were significantly attenuated: limb deficiencies, aORs/95%CIs = (0.44 [0.20–0.97]) and septal defects (0.69 [0.48–0.99]). After stratifying by years lived in the United States, the risk for hydrocephaly (2.43 [1.03–5.74]) became apparent among those having lived 6+ years in the United States. When restricting to African‐born mothers, none of the findings were statistically significant. Conclusions: Foreign‐born NH Blacks were at a reduced risk for a few selected defects. Results were consistent after restricting to African‐born mothers and did not change considerably when stratifying by years lived in the United States.