Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy. (15th February 2020)

• Record Type: Journal Article
• Authors: Nagata, Noriyuki; Ohta, Hiroshi; Yokoyama, Nozomu; Teoh, Yong Bin; Nisa, Khoirun; Sasaki, Noboru; Osuga, Tatsuyuki; Morishita, Keitaro; Takiguchi, Mitsuyoshi
• Is Part Of: Journal of veterinary internal medicine. Volume 34:Number 2(2020)
• Page Start: 659
• Page End: 668
• Publication Date: 2020-02-15
• Subjects: canine -- CCECAI -- chronic enteropathy -- CIBDAI -- clinical disease -- immunosuppressant -- intestinal lymphangiectasia -- ultralow‐fat diet; Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.15720
• Languages: English
• ISSNs: 0891-6640

Abstract

Abstract: Background: In dogs with protein‐losing enteropathy (PLE), data on the clinical characteristics of food‐responsive PLE (FR‐PLE) remain scarce. Objective: To determine the clinical characteristics of FR‐PLE in dogs responsive to ultralow‐fat diet (ULFD) management. Animals: Thirty‐three dogs diagnosed with PLE based on standard diagnostic criteria. Methods: Retrospective review of medical records. Clinical findings were compared between dogs with FR‐PLE (FR‐PLE group) and those with immunosuppressant‐responsive PLE (IR‐PLE) or nonresponsive PLE (NR‐PLE) (IR/NR‐PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR‐PLE and IR/NR‐PLE groups. Survival time was compared between the FR‐PLE and IR/NR‐PLE groups. Results: Twenty‐three dogs responded to ULFD management and were diagnosed with FR‐PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR‐PLE group than in the IR/NR‐PLE group ( P < .001). The AUC of CCECAI for differentiating the FR‐PLE group was 0.935 (95% confidence interval [CI], 0.845‐1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR‐PLE group (median, not reached) than in the IR/NR‐PLE group (median, 432 days; P < .001). Conclusions and Clinical Importance: Dogs that respond to ULFD management and are diagnosed with FR‐PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR‐PLE from IR‐PLE or NR‐PLE.