Anti‐MDA5‐associated dermatomyositis. Issue 4 (8th April 2020)

• Record Type: Journal Article
• Authors: Gupta, Rajiv; Kumar, Sunil; Gow, Peter; (Hsien‐Cheng) Chang, Leon; Yen, Linda
• Is Part Of: Internal medicine journal. Volume 50:Issue 4(2020)
• Page Start: 484
• Page End: 487
• Publication Date: 2020-04-08
• Subjects: inflammatory myopathy -- anti‐MDA5‐associated dermatomyositis -- MDA5‐associated interstitial lung disease -- cyclosporine -- intravenous immunoglobulins; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.14789
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract: Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP‐ILD). We report two cases of MDA5‐associated DM with fatal outcome in one of the patients, despite 'aggressive triple therapy' for RP‐ILD.