Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic–Pituitary–Adrenal Axis Reactivity. (3rd June 2020)

• Record Type: Journal Article
• Authors: Zhang, Alice; Price, Julianne L.; Leonard, David; North, Carol S.; Suris, Alina; Javors, Martin A.; Adinoff, Bryon
• Is Part Of: Alcoholism. Volume 44:Number 6(2020)
• Page Start: 1192
• Page End: 1203
• Publication Date: 2020-06-03
• Subjects: Alcohol Use Disorder -- Childhood Adversity -- HPA Axis -- Stress -- Trauma; Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.14334
• Languages: English
• ISSNs: 0145-6008

Abstract

Abstract : Background: Individuals with alcohol use disorder (AUD) and those who have experienced traumas or chronic stress exhibit dysregulated hypothalamic–pituitary–adrenal (HPA) axis reactivity. Whether and how trauma and stress histories interact with AUD to affect HPA axis reactivity has not been assessed. Methods: In the present study, 26 healthy male controls and 70 abstinent men with AUD were administered a pharmacologic probe [ovine corticotropin–releasing hormone (oCRH)] and psychosocial stressor to assess HPA axis reactivity. Plasma adrenocorticotropin hormone (ACTH) and cortisol were assessed every 10–20 minutes. Hierarchical clustering of multiple measures of trauma and stress identified 3 distinct clusters: childhood adversity, lifetime trauma, and chronic stress. General linear model procedures were used to examine main effects of group (AUD/control) and interaction effects of the 3 clusters upon net‐integrated ACTH and cortisol response. Results: We found that higher levels of childhood adversity, lifetime trauma, and chronic stress were each associated with blunted oCRH‐induced ACTH reactivity in controls, but not in the AUD group. Recent chronic stress within the prior 6 months had the strongest influence upon ACTH reactivity in the control group, and lifetime trauma, the least. Conclusions: Childhood adversity, lifetime trauma, and chronic stress likely exert persistent, measurable effects upon HPA axis functioning in healthy controls. This association appears to be masked in individuals with AUD, potentially confounding studies examining the effects of stress, adversity, and/or trauma upon the HPA axis in this population during the protracted withdrawal phase of recovery. Future work targeting stress exposure and reactivity should consider the heightened effect of previous alcohol use relative to past adversity and trauma. Abstract : Whether and how trauma and stress histories interact with alcohol use disorder (AUD) to affect stress response systems has not been assessed. We found that childhood adversity (as well as lifetime trauma and chronic stress) is inversely associated with blunted oCRH‐induced ACTH reactivity in healthy controls. This association is not evident in individuals with AUD. These findings suggest that the pharmacologic effects of alcohol on the hypothalamic‐pituitary‐adrenal axis may overwhelm the more subtle effects of environmental stressors.