Association between environmental tobacco smoke exposure and risk of type 2 diabetes mellitus in Chinese female never smokers: A population‐based cohort study. Issue 4 (21st November 2019)

• Record Type: Journal Article
• Authors: Huang, Chunyan; Chen, Gang; Zhang, Mingzhi; Lu, Yan; Hua, Yujie; Hu, Yihe; Jin, Jianrong; Zhou, Jinyi; Bian, Zheng; Guo, Yu; Li, Liming; Chen, Zhengming; Zhang, Jun
• Is Part Of: Journal of diabetes. Volume 12:Issue 4(2020)
• Page Start: 339
• Page End: 346
• Publication Date: 2019-11-21
• Subjects: cohort study -- environmental tobacco smoke -- type 2 diabetes; 队列研究 -- 环境烟雾暴露 -- 2型糖尿病; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.13001
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: Evidence for the association between environmental tobacco smoke (ETS) exposure and the risk of type 2 diabetes mellitus (T2DM) is limited. The aim of this study was to investigate this association in female never smokers. Methods: We analyzed 28 177 female participants of the China Kadoorie Biobank (CKB) in the Suzhou area, who were never smokers and had no diabetes. ETS exposure was defined as being exposed to other people's tobacco smoke either at home, workplace, or in public places at least 1 d/wk. Cox proportional hazard regression models were used to assess the association between ETS exposure and incident T2DM according to the frequency and duration of ETS exposure. Results: A total of 774 incident cases of T2DM were identified during a median 7.3‐year follow‐up. Compared with no ETS exposure, hazard ratios (95% CIs) for all ETS exposure, daily, and ≥ 14 h/wk ETS exposure were 1.17 (1.00‐1.37), 1.23 (1.04‐1.46), and 1.25 (1.03‐1.53), respectively. Moreover, a positive dose‐response relationship was observed between ETS exposure level and T2DM (all P <.05 for trend). Conclusions: This prospective study suggests that ETS exposure increases the risk of T2DM incidence with dose‐response relationship in female never smokers. Thus, reducing ETS exposure may help decrease the burden of T2DM in Chinese females. Abstract : Highlights This was the first report attempting to explore the association between environmental tobacco smoke (ETS) exposure and the risk of incident type 2 diabetes (T2DM) in a Chinese population cohort. Daily ETS exposure was associated with an approximately 23% higher risk of T2DM. 摘要: 背景: 关于环境烟雾暴露与2型糖尿病风险关联的证据有限, 本研究旨在在中国从未吸烟的女性中研究二者的关联。 方法: 我们分析了中国慢性病前瞻性研究苏州地区28177名从未吸烟且无糖尿病女性参与者。环境烟雾暴露的定义为在家中、工作场所或公共场所至少1天/周暴露于他人的吸烟烟雾。使用Cox比例风险回归模型评估环境烟雾暴露频率和持续时间与2型糖尿病发病事件的关联。 结果: 在平均7.5人年的随访期间, 共发现774例2型糖尿病事件。与无环境烟雾暴露者相比, 有环境烟雾暴露史、频率为每日和时长≥14h/周的人群2型糖尿病发病风险比(95%CI)分别为1.17(1.00‐1.37), 1.23 (1.04‐1.46)和 1.25 (1.03‐1.53)。此外, 环境烟雾暴露水平和2型糖尿病风险之间呈现剂量反应性的正关联(所有Ptrend<0.05)。 结论: 这项前瞻性研究表明, 在从未吸烟的女性中, 环境烟雾暴露会增加2型糖尿病的发病风险, 并具有剂量反应关系。 因此, 减少环境烟雾暴露可能有助于减轻中国女性的2型糖尿病负担。