Assessing the validity of eyelid parameters to detect impairment due to benzodiazepines. (5th February 2020)

• Record Type: Journal Article
• Authors: Wilkinson, Vanessa E.; Jackson, Melinda L.; Westlake, Justine; Stevens, Bronwyn; Barnes, Maree; Cori, Jennifer; Swann, Philip; Howard, Mark E.
• Is Part Of: Human psychopharmacology. Volume 35:Number 2(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-05
• Subjects: behavioural lapses -- benzodiazepines -- eye blinks -- eyelid parameters -- ocular measures -- temazepam; Psychopharmacology -- Periodicals; Psychotropic drugs -- Periodicals; Psychopharmacology -- Periodicals; Psychotropic Drugs -- pharmacology -- Periodicals; 615.78
• DOI: 10.1002/hup.2723
• Languages: English
• ISSNs: 0885-6222

Abstract

Abstract: Objective: Benzodiazepines impair driving ability and psychomotor function. Eyelid parameters accurately reflect drowsiness; however, the effects of benzodiazepines on these measures have not been extensively studied. The aim of this study was to investigate the effect of benzodiazepines on eyelid parameters and evaluate their accuracy for detecting psychomotor impairment. Methods: Eyelid parameters were recorded during a psychomotor vigilance task (PVT) and driving simulation over 2 days, baseline, and after 20‐mg oral temazepam. The utility of eyelid parameters for detecting PVT lapses was evaluated using receiver operating characteristic curves, and cut‐off levels indicating impairment (≥1 and ≥2 PVT lapses per min) were identified. The accuracy of these cut‐off levels for detecting driving simulator crashes was then examined. Results: PVT and driving simulator performance was significantly impaired following benzodiazepine administration ( p < .05). Average eyelid closure duration (inter‐event duration) was a reliable indicator of PVT lapses (area under the curve [AUC] of 0.87–0.90). The cut‐off value of eyelid closure duration derived from PVT AUC was able to predict driving simulator crashes with moderately high sensitivity and specificity (76.23% and 75.00%). Conclusions: Eyelid parameters were affected by benzodiazepines and accurately detected the psychomotor impairment. In particular, eyelid closure duration is a promising real‐time indicator of benzodiazepine impairment.