Natural products for the prevention and treatment of cholestasis: A review. (5th February 2020)

• Record Type: Journal Article
• Authors: Ma, Xiao; Jiang, Yinxiao; Zhang, Wenwen; Wang, Jiabo; Wang, Ruilin; Wang, Lifu; Wei, Shizhang; Wen, Jianxia; Li, Haotian; Zhao, Yanling
• Is Part Of: Phytotherapy research. Volume 34:Number 6(2020)
• Page Start: 1291
• Page End: 1309
• Publication Date: 2020-02-05
• Subjects: bile acids homeostasis -- cholestasis -- liver injury -- multiple targets -- natural products; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.6621
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Cholestasis is a common manifestation of decreased bile flow in various liver diseases. It results in fibrosis and even cirrhosis without proper treatment. It is believed that a wide range of factors, including transporter dysfunction, oxidative stress, inflammatory damage, and immune disruption, can cause cholestasis. In recent years, natural products have drawn much attention for specific multiple‐target activities in diseases. Many attempts have been made to investigate the anticholestatic effects of natural products with advanced technology. This review summarizes recent studies on the biological activities and mechanisms of recognized compounds for cholestasis treatment. Natural products, including various flavonoids, phenols, acids, quinones, saponins, alkaloids, glycosides, and so on, function as comprehensive regulators via ameliorating oxidative stress, inflammation, and apoptosis, restoring bile acid balance with hepatic transporters, and adjusting immune disruption. Moreover, in this progress, nuclear factor erythroid 2‐related factor 2, reactive oxygen species production, heme oxygenase‐1, NF‐κB, cholesterol 7 alpha‐hydroxylase, and farnesoid X receptors are thought as main targets for the activity of natural products. Therefore, this review presents the detailed mechanisms that include multiple targets and diverse signalling pathways. Natural products are the valuable when seeking novel therapeutic agents to treat cholestatic liver diseases.