The correlation between serum apolipoprotein B/apolipoprotein A1 ratio and brain necrosis in patients underwent radiotherapy for nasopharyngeal carcinoma. Issue 3 (3rd February 2020)

• Record Type: Journal Article
• Authors: Li, Honghong; Zheng, Dong; Xie, Fukang; Huang, Xiaolong; Zhuo, Xiaohuang; Lin, Jinpeng; Li, Yi; Tang, Yamei
• Is Part Of: Brain and behavior. Volume 10:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-03
• Subjects: apolipoprotein B/apolipoprotein A1 ratio -- nasopharyngeal carcinoma -- quality of life -- radiation‐induced brain necrosis; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.1554
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Introduction: The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio is recognized as a clinical indicator of cardiovascular disease and ischemic cerebral disease. Cerebrovascular dysfunction is also involved in head and neck radiotherapy. The aim of this study was to investigate the correlation between ApoB/ApoA1 ratio and the severity of radiation‐induced brain necrosis (RN) in patients who underwent radiotherapy after nasopharyngeal carcinoma (NPC). Methods: In this retrospective study, 191 NPC patients diagnosed with RN were evaluated. Clinical characteristics, serum lipid, apolipoproteins, and brain magnetic resonance imaging findings were collected. Serum lipid and apolipoproteins were quantified using standard diagnostic assays, and the quality of life (QOL) was assessed by the World Health Organization quality of life abbreviated instrument (WHOQOL‐BREF). Results: ApoB/ApoA1 ratio was positively correlated with lesion volume ( r = .18, p = .03) and negatively correlated with WHOQOL‐BREF scores ( r = −.28, p < .01). The ApoB/ApoA1 ratio and intensity‐modulated radiation therapy (IMRT) were independent risk factor of RN volume. Moreover, ApoB/ApoA1 ratio was significantly negatively correlated with physical health ( r = −.29, p < .01), psychological ( r = −.27, p < .01), social relationships ( r = −.17, p = .02), and environment ( r = −.27, p < .01) domains of WHOQOL‐BREF. Conclusions: Serum ApoB/ApoA1 ratio is positively correlated with RN volume, which indicated serum ApoB/ApoA1 ratio as an independent risk factor for lesion volume in patients with RN after radiotherapy for NPC, suggesting a bright intervention target in RN treatment. Abstract : Radiotherapy causes burdensome side effects that seriously affected the quality of life (QOL). Apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio was positively correlated with radiotherapy induce brain necrosis (RN) volume and negatively correlated with QOL. ApoB/ApoA1 ratio was an independent risk factor of RN volume, suggesting a bright intervention target in RN treatment.