Fluorescence Self‐Reporting Precipitation Polymerization Based on Aggregation‐Induced Emission for Constructing Optical Nanoagents. Issue 25 (9th January 2020)

• Record Type: Journal Article
• Authors: Wang, Guan; Zhou, Liangyu; Zhang, Pengfei; Zhao, Engui; Zhou, Lihua; Chen, Dong; Sun, Jiangman; Gu, Xinggui; Yang, Wantai; Tang, Ben Zhong
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 25(2020)
• Page Start: 10122
• Page End: 10128
• Publication Date: 2020-01-09
• Subjects: aggregation-induced emission -- fluorescence -- optical nanoagents -- photo-controllable immunotherapy -- precipitation polymerization; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201913847
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Precipitation polymerization is becoming increasingly popular in energy, environment and biomedicine. However, its proficient utilization highly relies on the mechanistic understanding of polymerization process. Now, a fluorescence self‐reporting method based on aggregation‐induced emission (AIE) is used to shed light on the mechanism of precipitation polymerization. The nucleation and growth processes during the copolymerization of a vinyl‐modified AIEgen, styrene, and maleic anhydride can be sensitively monitored in real time. The phase‐separation and dynamic hardening processes can be clearly discerned by tracking fluorescence changes. Moreover, polymeric fluorescent particles (PFPs) with uniform and tunable sizes can be obtained in a self‐stabilized manner. These PFPs exhibit biolabeling and photosensitizing abilities and are used as superior optical nanoagents for photo‐controllable immunotherapy, indicative of their great potential in biomedical applications. Abstract : A fluorescence self‐reporting method based on aggregation‐induced emission has been developed to unveil the mechanism of precipitation polymerization. Morphology and microenvironment changes are subtly discerned in the nucleation and growth processes. Polymeric fluorescent particles with uniform and tunable sizes are well‐designed to act as optical nanoagents for photo‐controllable immunotherapy.