A four‐compartment multiscale model of fluid and drug distribution in vascular tumours. (25th February 2020)

• Record Type: Journal Article
• Authors: Shipley, Rebecca J.; Sweeney, Paul W.; Chapman, Stephen J.; Roose, Tiina
• Is Part Of: International journal for numerical methods in biomedical engineering. Volume 36:Number 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-25
• Subjects: cancer -- chemotherapy -- homogenisation -- mathematical modelling -- vasculature; Biomedical engineering -- Periodicals; Imaging systems in medicine -- Periodicals; Numerical analysis -- Periodicals; Engineering mathematics -- Periodicals; 610.28
• DOI: 10.1002/cnm.3315
• Languages: English
• ISSNs: 2040-7939

Abstract

Abstract: The subtle relationship between vascular network structure and mass transport is vital to predict and improve the efficacy of anticancer treatments. Here, mathematical homogenisation is used to derive a new multiscale continuum model of blood and chemotherapy transport in the vasculature and interstitium of a vascular tumour. This framework enables information at a range of vascular hierarchies to be fed into an effective description on the length scale of the tumour. The model behaviour is explored through a demonstrative case study of a simplified representation of a dorsal skinfold chamber, to examine the role of vascular network architecture in influencing fluid and drug perfusion on the length scale of the chamber. A single parameter, P, is identified that relates tumour‐scale fluid perfusion to the permeability and density of the capillary bed. By fixing the topological and physiological properties of the arteriole and venule networks, an optimal value for P is identified, which maximises tumour fluid transport and is thus hypothesised to benefit chemotherapy delivery. We calculate the values for P for eight explicit network structures; in each case, vascular intervention by either decreasing the permeability or increasing the density of the capillary network would increase fluid perfusion through the cancerous tissue. Chemotherapeutic strategies are compared and indicate that single injection is consistently more successful compared with constant perfusion, and the model predicts optimal timing of a second dose. These results highlight the potential of computational modelling to elucidate the link between vascular architecture and fluid, drug distribution in tumours. Abstract : A novel multiscale continuum model is derived using mathematical homogenisation to predict the delivery of blood and chemotherapy through the vasculature and interstitium of a vascular tumour. Here, the model is used to elucidate the influence of vascular architecture on fluid and drug perfusion in a dorsal skinfold chamber. We identify an optimal permeability and density of the capillary bed, which maximises blood perfusion, and show that single injection of a chemotherapy is more successful than constant perfusion.