Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults. Issue 5 (25th January 2020)

• Record Type: Journal Article
• Authors: Maltais, Mathieu; de Souto Barreto, Philipe; Perus, Lisa; Mangin, Jean‐François; Grigis, Antoine; Chupin, Marie; Bouyahia, Ali; Gabelle, Audrey; Delrieux, Julien; Rolland, Yves; Vellas, Bruno
• Other Names: Vellas Bruno investigator.; Guyonnet Sophie investigator.; Carrié Isabelle investigator.; Brigitte Lauréane investigator.; Faisant Catherine investigator.; Lala Françoise investigator.; Delrieu Julien investigator.; Villars Hélène investigator.; Combrouze Emeline investigator.; Badufle Carole investigator.; Zueras Audrey investigator.; Andrieu Sandrine investigator.; Cantet Christelle investigator.; Morin Christophe investigator.; Van Kan Gabor Abellan investigator.; Dupuy Charlotte investigator.; Rolland Yves investigator.; Caillaud Céline investigator.; Ousset Pierre‐Jean investigator.; Lala Françoise investigator.; Dartigues Jean‐François investigator.; Marcet Isabelle investigator.; Delva Fleur investigator.; Foubert Alexandra investigator.; Cerda Sandrine investigator.; Marie‐Noëlle‐Cuffi investigator.; Costes Corinne investigator.; Rouaud Olivier investigator.; Manckoundia Patrick investigator.; Quipourt Valérie investigator.; Marilier Sophie investigator.; Franon Evelyne investigator.; Bories Lawrence investigator.; Pader Marie‐Laure investigator.; Basset Marie‐France investigator.; Lapoujade Bruno investigator.; Faure Valérie investigator.; LiYungTong Michael investigator.; Malick‐Loiseau Christine investigator.; Cazaban‐Campistron Evelyne investigator.; Desclaux Françoise investigator.; Blatge Colette investigator.; Dantoine Thierry investigator.; Laubarie‐Mouret Cécile investigator.; Saulnier Isabelle investigator.; Clément Jean‐Pierre investigator.; Picat Marie‐Agnès investigator.; Bernard‐Bourzeix Laurence investigator.; Willebois Stéphanie investigator.; Désormais Iléana investigator.; Cardinaud Noëlle investigator.; Bonnefoy Marc investigator.; Livet Pierre investigator.; Rebaudet Pascale investigator.; Gédéon Claire investigator.; Burdet Catherine investigator.; Terracol Flavien investigator.; Pesce Alain investigator.; Roth Stéphanie investigator.; Chaillou Sylvie investigator.; Louchart Sandrine investigator.; Sudres Kristelle investigator.; Lebrun Nicolas investigator.; Barro‐Belaygues Nadège investigator.; Touchon Jacques investigator.; Bennys Karim investigator.; Gabelle Audrey investigator.; Romano Aurélia investigator.; Touati Lynda investigator.; Marelli Cécilia investigator.; Pays Cécile investigator.; Robert Philippe investigator.; Le Duff Franck investigator.; Gervais Claire investigator.; Gonfrier Sébastien investigator.; Gasnier Yannick investigator.; Bordes Serge investigator.; Begorre Danièle investigator.; Carpuat Christian investigator.; Khales Khaled investigator.; Lefebvre Jean‐François investigator.; Misbah El Idrissi Samira investigator.; Skolil Pierre investigator.; Salles Jean‐Pierre investigator.; Dufouil Carole investigator.; Lehéricy Stéphane investigator.; Chupin Marie investigator.; Mangin Jean‐François investigator.; Bouhayia Ali investigator.; Allard Michèle investigator.; Ricolfi Frédéric investigator.; Dubois Dominique investigator.; Martel Marie Paule Bonceour investigator.; Cotton François investigator.; Bonafé Alain investigator.; Chanalet Stéphane investigator.; Hugon Françoise investigator.; Bonneville Fabrice investigator.; Cognard Christophe investigator.; Chollet François investigator.; Payoux Pierre investigator.; Voisin Thierry investigator.; Delrieu Julien investigator.; Peiffer Sophie investigator.; Hitzel Anne investigator.; Allard Michèle investigator.; Zanca Michel investigator.; Monteil Jacques investigator.; Darcourt Jacques investigator.; Molinier Laurent investigator.; Derumeaux Hélène investigator.; Costa Nadège investigator.; Perret Bertrand investigator.; Vinel Claire investigator.; Caspar‐Bauguil Sylvie investigator.;
• Is Part Of: Journal of the American Geriatrics Society. Volume 68:Issue 5(2020)
• Page Start: 1050
• Page End: 1055
• Publication Date: 2020-01-25
• Subjects: brain health -- diffusion magnetic resonance imagingfrailty -- physical capacity; Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.16343
• Languages: English
• ISSNs: 0002-8614

Abstract

Abstract : BACKGROUND: Cross‐sectional associations have been found between frail individuals and worse white matter (WM) integrity. However, the prospective association between WM integrity and frailty is still unclear. Our objectives were to measure associations between WM integrity using diffusion tensor imaging (DTI) and the 5‐year worsening of frailty in community‐dwelling older adults. DESIGN: Secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT). SETTING: Thirteen memory centers in France and Monaco between 2008 and 2011. PARTICIPANTS: Participants (mean age = 74.7 ± 3.9 years) with no dementia at baseline who had functional magnetic resonance imaging performed as part of the MAPT study (n = 227). MEASUREMENTS: Fractional anisotropy and mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) were acquired for 10 different brain regions. Frailty was assessed by the Fried frailty phenotype (score from 0 to 5, higher is worse) at up to seven time points for 5 years. Mixed effect ordinal logistic regression model was used to assess the prospective association between DTI parameters (independent variables) and frailty (dependent variable). All the analyses were adjusted for age, sex, baseline total intracranial volume, and the presence of one of the following cardiovascular risk factors (hypertension, diabetes, and/or hypercholesterolemia). RESULTS: A statistically significant association was found between the RD, AxD, and MD for different brain regions (anterior limb of internal capsule, external capsule, posterior corona radiata, posterior thalamic radiation, superior corona radiata, superior frontal occipital fasciculus, and superior longitudinal fasciculus) and worsening of frailty over 5 years after adjusting for multiple comparisons. CONCLUSIONS: This is the first study to show that WM integrity is associated with frailty in older adults. The mechanisms related to these results require further investigation. J Am Geriatr Soc 68:1050–1055, 2020