Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers. Issue 3 (3rd February 2020)

• Record Type: Journal Article
• Authors: Denkova, Antonia G.; Liu, Huanhuan; Men, Yongjun; Eelkema, Rienk
• Is Part Of: Advanced therapeutics. Volume 3:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-03
• Subjects: chemotherapy -- nanocarriers -- radiosensitizers -- radiotherapy; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.201900177
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: Next to surgery, radiotherapy and chemotherapy are the two most commonly applied treatments against cancer. These therapies are often combined, but the therapeutic outcome is still limited. Nanocarriers may be the solution to many of the issues encountered when combining these therapies. In this review, the role of nanocarriers in combined radiotherapy and chemical cancer treatment is discussed, divided into four distinct strategy classes. For each strategy, examples of the literature are given to come eventually to conclusion on the possible translation to the clinic. Abstract : The role of nanocarriers in combined radiotherapy and cancer treatment employing chemicals is reviewed. Four different strategies are discussed: 1) delivery of multifunctional drugs; 2) enhanced targeting or tumor uptake in concurrent radiotherapy and drug delivery; 3) enhancing the effect of ionizing radiation; and 4) controlled release using ionizing radiation as a trigger.